IMMUNOSTIMULANT COMPOSITIONS COMPRISING AN AMINOALKYL GLUCOSAMINIDE PHOSPHATE AND QS-21

摘要

The invention provides pharmaceutical compositions, particularly vaccine compositions, employing an adjuvant system comprising RC-529 (an aminoalkyl glucosaminide phosphate compound) and QS-21 (a saponin). Such compositions synergistically enhance the immune response in a mammal to a co-administered antigen. Also provided are methods of using the compositions in the treatment of various human diseases, including cancer, microbial infections and autoimmune disorders.