发明名称 |
GENETIC TESTING FOR DETERMINING THE RISK OF POUCHITIS DEVELOPMENT |
摘要 |
The present invention provides a method of determining a risk of pouchitis development following a surgical procedure where an internal pouch is create d in a patient with ulcerative colitis. The method is practiced by determining in the patient the presence or absence of a pouchitis-associated allele link ed to an interferon .gamma. receptor locus, where the presence of the pouchitis - associated allele indicates an increased risk of pouchitis development. The interferon .gamma. receptor locus to which the pouchitis-associated allele i s linked can be, for example, an interferon .gamma. receptor 1 gene. A pouchit is- associated allele useful in the invention can be, for example, an allele located within the sixth intron of the interferon .gamma. receptor 1 gene, such as a FA1 microsatellite 171 allele.
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申请公布号 |
CA2406346(A1) |
申请公布日期 |
2001.10.25 |
申请号 |
CA20012406346 |
申请日期 |
2001.04.10 |
申请人 |
CEDARS-SINAI MEDICAL CENTER |
发明人 |
TAYLOR, KENT D.;YANG, HUIYING;ROTTER, JEROME I.;FLESHNER, PHILLIP R. |
分类号 |
G01N33/483;C12N15/09;C12Q1/68;G01N27/447;G01N33/50;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/483 |
代理机构 |
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主权项 |
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地址 |
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