| 发明名称 |
PHOSPHORYLATED GLYCOSIDASE INHIBITOR PRODRUGS |
| 摘要 |
A method is provided for converting therapeutic glycosidase inhibitors to novel prodrugs by phosphorylation of a free hydroxyl group on the molecule to substantially reduce the glycosidase inhibitory activity without thereby substantially reducing the therapeutic activity.
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| 申请公布号 |
CA2023404(C) |
申请公布日期 |
2001.10.23 |
| 申请号 |
CA19902023404 |
申请日期 |
1990.08.16 |
| 申请人 |
MONSANTO COMPANY |
发明人 |
DWEK, RAYMOND A.;SCUDDER, PETER R.;JACOB, GARY S.;RADEMACHER, THOMAS W. |
| 分类号 |
A61K31/445;A61K31/675;A61P3/06;A61P3/08;A61P31/12;A61P43/00;C07F9/09;C07F9/59;C12P9/00;C12P17/12;(IPC1-7):C12P17/12;A61K31/44 |
主分类号 |
A61K31/445 |
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