发明名称 |
NUCLEOTIDE SEQUENCES OF AVIAN HERPES VIRUSES |
摘要 |
<p>Various genes of herpes virus of turkeys (HVT), Marek's disease virus (MDV) and infectious laryngotracheitis virus (ILTV) have been identified as non-essential regions (and candidates for insertion sites for foreign genes) and/or as antigen-encoding regions. The former include the HVT homologue of the HSV (herpes simplex virus) gC gene, the TK (thymidine kinase) region of MDV or ILTV, ORF3 of ILTV (as defined herein), the ribonucleotide reductase (large subunit) gene of ILTV, MDV or HVT and the ribonucleotide reductase (small subunit) gene of MDV. The antigen-encoding regions include the HVT homologues of the HSV gB, gC and gH genes, the ILTV homologue of HSV gB, ORF2 of ILTV, and the HVT homologue of the HSV-1 immediate early genes IE-175 and IE-68. Manipulation of these genes allows vaccines to be prepared comprising attenuated virus or virus carrying heterologous antigen-encoding sequences.</p> |
申请公布号 |
CA1341307(C) |
申请公布日期 |
2001.10.23 |
申请号 |
CA19890611209 |
申请日期 |
1989.09.13 |
申请人 |
INSTITUTE FOR ANIMAL HEALTH LIMITED |
发明人 |
BINNS, MATTHEW MCKINLEY;SCOTT, SIMON DAVID;GRIFFIN, ANNETTE MARY;ROSS, LOUIS JOSEPH NORMAN |
分类号 |
A01K67/027;A61K31/00;A61K35/76;A61K38/00;A61K39/00;A61K39/215;A61K39/245;A61K39/255;A61K39/265;A61K39/275;A61K39/295;A61K48/00;A61P31/00;A61P31/12;A61P31/20;A61P31/22;A61P37/04;C07K14/03;C07K14/035;C07K14/055;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N7/00;C12N7/01;C12N7/04;C12N9/02;C12N9/12;C12N15/00;C12N15/09;C12N15/38;C12N15/45;C12N15/869;C12P21/02;C12R1/91;C12R1/92;(IPC1-7):C12N15/38;C12N15/86;C12N15/63 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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