| 摘要 |
PROBLEM TO BE SOLVED: To obtain a nonpeptide stable in living organisms and capable of being orally administered which has calcitonin receptor agent action and also shows calcitonin-like action in living organisms. SOLUTION: This calcitonin receptor agonist comprises at least one selected from the group consisting of pyridones represented by the general formula (wherein R1 is H, hydroxyl group, a 1-4C alkyloxy group or a 7-10C aralkyloxy group; R2 and R3 are each a 1-4C alkyl group; and R4 and R5 are each H, a halogen atom, hydroxyl group, a 1-4C alkyl group, a 7-10C aralkyl group, a 1-4C alkyloxy group, a 7-10C aralkyloxy group, a 1-7C acyloxy group, amino group, a 1-4C alkylamino group, a 17-10C aralkylamino group, a 1-7C acylamino group, carboxyl group, a 1-4C alkyloxycarbonyl group, a 7-10C aralkyloxycarbonyl group, a carbamoyl group allowed to have at least one substituent, an acyl group or sulfamoyl group) and pharmacologically permissible salts thereof as an active component.
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