发明名称 |
Substituted lactams as inhibitors of abeta protein production |
摘要 |
This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Abeta-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta-amyloid production such as Alzheimer's disease and Down's Syndrome. |
申请公布号 |
AU5700601(A) |
申请公布日期 |
2001.10.23 |
申请号 |
AU20010057006 |
申请日期 |
2001.04.11 |
申请人 |
DU PONT PHARMACEUTICALS COMPANY |
发明人 |
WEI HAN;HONG LIU;RICHARD E. OLSON;MICHAEL G. YANG |
分类号 |
C07D243/26;A61K31/55;A61K31/5513;A61P25/28;A61P43/00;C07D223/12;C07D223/18;C07D243/12;C07D243/24;C07D401/04 |
主分类号 |
C07D243/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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