发明名称 |
Neutralizing immunogenic hev polypeptides |
摘要 |
The present invention provides immunogenic Hepatitis E Virus polypeptides and methods of use. The polypeptides include at least one neutralizing antigenic epitope and preferably contain at least about fifty amino acids residues between amino acid residues 452 and 617 from the C-terminal of the HEV pORF2 protein. The polypeptides are useful, alone or in combination with other polypeptides of the present invention, as a reagent for studying the pathogenesis of HEV and monitoring treatment efficacy in subjects undergoing treatment for HEV. Further, the polypeptides can be used as a vaccine to treat or prevent HEV. |
申请公布号 |
AU5125001(A) |
申请公布日期 |
2001.10.23 |
申请号 |
AU20010051250 |
申请日期 |
2001.04.03 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED |
发明人 |
HOWARD A FIELDS;YURY E KHUDYAKOV;JIHONG MENG |
分类号 |
A61K39/00;C07K14/08 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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