2-FORMYLBENZYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF DISEASES CAUSED BY VIRUSES

摘要

2-Formylbenzylphosphonic acid derivatives, their prepar- ation and their use for the treatment of diseases caused by viruses The compound of the formula I in which R is an aldehyde group or a group which can be converted into an aldehyde, R1 and R2 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potas- sium, calcium, magnesium, aluminum, lithium, ammonium or triethylammonium, or R1 and R2 together form a cyclic diester, R3 and R4 are alkyl, alkenyl, alkynyl, cycloalkyl, hydro- gen, alkoxy or halogen, R5 and R8 are alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, and X, Y or Z are oxygen or sulfur, or prodrug forms of the compound of the formula I can be used for the treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations containing them and their use is described.