PROCESS FOR PREPARING OPTICALLY ACTIVE AMINOPENTANE DERIVATIVES

摘要

A novel practical process for preparing optically active 1-(benzofuran-2-yl)-2-propylaminopentane derivatives useful as drugs, particularly psychotropic drug, antidepressant, antiparkinson drug, or antialzheimer drug. This process comprises using optically active aziridine or amide compounds which can be prepared from optically active amino acids with the chirality maintained and makes it possible to prepare optically active 1-(benzofuran-2-yl)-2-propylaminopentane derivatives or pharmaceutically acceptable salts thereof without a special catalyst, through extremely simple and easy operation, at high purity, with high selectivity, and in high yield.