METHOD FOR DETECTING A HORMONE DISRUPTING ACTIVITY OF ENVIRONMENTAL POLLUTANTS

摘要

A method for detecting a hormone disrupting activity of environmental pollutants, comprising binding a steroid or thyroid hormone transport protein from blood of a mammal to a solid carrier via a specific antibody to the transport protein, and subsequently incubating the solid carrier with a corresponding labelled hormone and the substance to be tested for a sufficiently long period of time in order to let competition of the labelled hormone and the substance to be tested for binding sites on the transport protein take place, wherein a measure for the hormone disrupting activity is obtained on the basis of the degree of displacement of the labelled hormone from the transport protein.