发明名称 |
COMPOUNDS AND METHODS FOR LOWERING CHOLESTEROL LEVELS WITHOUT INDUCING HYPERTRIGLYCERIDEMIA |
摘要 |
This invention provides methods of lowering cholesterol, delaying the onset of atherosclerosis, or treating atherosclerosis in a mammal without inducing hypertriglyceridemia. These methods involve administering to or expressing in a mammal, an apoE polypeptide or nucleic acid that, when administered to or expressed in a mammal, lowers the total serum cholesterol level without inducing hypertriglyceridemia.
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申请公布号 |
WO0177136(A1) |
申请公布日期 |
2001.10.18 |
申请号 |
WO2001US11358 |
申请日期 |
2001.04.06 |
申请人 |
KOS PHARMACEUTICALS, INC.;TRUSTEES OF BOSTON UNIVERSITY |
发明人 |
ZANNIS, VASSILIS, I.;KYPREOS, KYRIAKOS, E. |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P3/06;A61P9/10;C07K14/775;C12N5/08;(IPC1-7):C07H21/04;C12N5/00;C12N15/00;C12N15/63;C12N15/86;C12N15/88 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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