发明名称 |
COMPOUNDS AND METHODS TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY |
摘要 |
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
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申请公布号 |
CA2404044(A1) |
申请公布日期 |
2001.10.18 |
申请号 |
CA20012404044 |
申请日期 |
2001.04.11 |
申请人 |
ATHEROGENICS, INC. |
发明人 |
MENG, CHARLES Q.;SIKORSKI, JAMES;LUCHOOMUN, JAYRAZ;SAXENA, UDAY |
分类号 |
A61K31/7034;A61K31/10;A61K31/192;A61K31/198;A61K31/255;A61P3/06;C07C323/20;G01N33/92;(IPC1-7):C07C323/20 |
主分类号 |
A61K31/7034 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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