HYPOTENSORS

摘要

A method of selecting a substance capable of controlling the activation of prorenin with the use of, as an indication, the ability to control the activation of prorenin by an interaction between proteins in the profragment domain of prorenin; a prorenin activation controlling substance which has a function of controlling the activation of prorenin based on the interaction between proteins in the profragment domain of prorenin; and hypotensors, org an overgrowth inhibitors and arterial thickening inhibitors containing the abov e- described prorenin activation controlling substance as the active ingredient .