发明名称 |
TAMANDARIN AND DIDEMNIN ANALOGS AND METHODS OF MAKING AND USING THEM |
摘要 |
The present invention relates to didemnin analogs, including tamandarin analogs and didemnin and tamandarin analogs which have a deoxo-proline residue or a dehydro-proline residue in their structure. These analogs are useful as anti-cancer agents and for other purposes. Methods of making these analogs and methods of using them as inhibitors of protein synthesis, cell growth, and tumorigenesis and as enhancers of apoptosis are also provided.
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申请公布号 |
WO0176616(A1) |
申请公布日期 |
2001.10.18 |
申请号 |
WO2001US11607 |
申请日期 |
2001.04.09 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA;JOULLIE, MADELEINE, M.;LIANG, BO;DING, XIAOBIN |
发明人 |
JOULLIE, MADELEINE, M.;LIANG, BO;DING, XIAOBIN |
分类号 |
A61K38/00;A61P9/10;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/06;A61P37/08;A61P43/00;C07K5/02;C07K5/083;C07K7/02;C07K11/00;(IPC1-7):A61K38/00;A61K38/12;A61K38/14;C07K17/00;C07K9/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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