发明名称 |
SUBSTITUTED LACTAMS AS INHIBITORS OF A beta PROTEIN PRODUCTION |
摘要 |
This invention relates to novel lactams of Formula (I) having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A beta -peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to beta -amyloid production such as Alzheimer's disease and Down's Syndrome.
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申请公布号 |
WO0177086(A1) |
申请公布日期 |
2001.10.18 |
申请号 |
WO2001US11714 |
申请日期 |
2001.04.11 |
申请人 |
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发明人 |
HAN, WEI;LIU, HONG;OLSON, RICHARD, E.;YANG, MICHAEL, G. |
分类号 |
C07D243/26;A61K31/55;A61K31/5513;A61P25/28;A61P43/00;C07D223/12;C07D223/18;C07D243/12;C07D243/24;C07D401/04;(IPC1-7):C07D243/24;C07K5/06;A61K38/00;A61K31/551 |
主分类号 |
C07D243/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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