摘要 |
<p>The invention provides collections of orthogonally-protected monosaccharides as universal building blocks for the synthesis of glycoconjugates of non-carbohydrate molecules, neo-glycoconjugates and oligosaccharides. This orthogonal protection strategy allows for the specific deprotection of any substituent ono the saccharide ring, and greatly facilitates targeted or library-focused carbohydrate-related syntheses. In particular, the invention provides a universal monosaccharide building block of General Formula (I) or General Formula (II) in which A is a leaving group; X is hydrogen, O, N or N<SUB>3</SUB>; X<SUB>1 </SUB>is hydrogen, -CH<SUB>2</SUB>O-, -CH<SUB>2</SUB>NH-, -CH<SUB>3</SUB>, -CH<SUB>2</SUB>N<SUB>3 </SUB>or -COO-; and B, C, D and E are protecting groups that can be cleaved orthogonally, and in which B, C, D and E are absent when X is hydrogen or N<SUB>3</SUB>, and E is absent when X<SUB>1 </SUB>is hydrogen, CH<SUB>3 </SUB>or N<SUB>3</SUB>.</p> |