发明名称 |
NOVEL HYDROGEL ISOLATED COCHLEATE FORMULATIONS, PROCESS OF PREPARATION AND THEIR USE FOR THE DELIVERY OF BIOLOGICALLY RELEVANT MOLECULES |
摘要 |
<p>A process for producing a small-sized, lipid-based cochleates. Cochleates are derived from liposomes which are suspended in an aqueous two-phase polymer solution, enabling the differential partitioning of polar molecule based-structures by phase separation. The liposome-containing two-phase polymer solution, treated with positively charged molecules such as Ca2+ or Zn2+, forms a cochleate precipitate of a particle size less than one micron. The process may be used to produce cochleates containing biologically relevant molecules.</p> |
申请公布号 |
EP1143933(A2) |
申请公布日期 |
2001.10.17 |
申请号 |
EP20000909961 |
申请日期 |
2000.01.24 |
申请人 |
BIODELIVERY SCIENCES, INC.;UNIVERSITY OF MEDICINE &, DENTISTRY OF NEW JERSEY |
发明人 |
ZARIF, LEILA;JIN, TUO;SEGARRA, IGNACIO;MANNINO, RAPHAEL |
分类号 |
C07D233/60;A61K9/00;A61K9/127;A61K31/05;A61K31/192;A61K31/198;A61K31/216;A61K31/337;A61K31/405;A61K31/4174;A61K31/436;A61K31/4422;A61K31/48;A61K31/522;A61K31/568;A61K31/704;A61K31/7042;A61K31/7048;A61K45/00;A61K47/02;A61K47/24;A61K47/30;A61K47/34;A61K47/36;A61K47/42;A61K47/44;A61P9/10;A61P23/00;A61P25/20;A61P29/00;A61P31/04;A61P31/10;A61P31/12;A61P35/00;A61P37/06;C07D209/26;C07D211/90;C07D305/00;C07D473/18;C07D519/00;C07J1/00;(IPC1-7):A61K9/127 |
主分类号 |
C07D233/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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