| 发明名称 |
Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex |
| 摘要 |
The present invention relates to compositions and crystals of a hepatitis C virus protease in complex with its viral cofactor. This invention also relates to methods of using the structure coordinates of hepatitis C virus protease in complex with a synthetic NS4A to solve the structure of similar or homologous proteins or protein complexes.
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| 申请公布号 |
US6303287(B1) |
申请公布日期 |
2001.10.16 |
| 申请号 |
US19990257667 |
申请日期 |
1999.02.25 |
| 申请人 |
VERTEX PHARMACEUTICALS, INCORPORATED |
发明人 |
KIM JOSEPH L.;MORGENSTERN KURT A.;LIN CHAO;FOX TED;THOMSON JOHN A. |
| 分类号 |
C07K1/00;C07K14/18;C07K19/00;C30B7/00;G01N33/576;G06F17/30;G06F19/00;(IPC1-7):C12Q1/00;C12Q1/68;C12Q1/37;C12N9/00 |
主分类号 |
C07K1/00 |
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