发明名称 |
Heart homing peptides and methods of using same |
摘要 |
The present invention provides a heart homing peptide that contains the amino acid sequence GGGVFWQ (SEQ ID NO: 2); HGRVRPH (SEQ ID NO: 3); VVLVTSS (SEQ ID NO: 4); CLHRGNSC (SEQ ID NO: 9); or CRSWNKADNRSC (SEQ ID NO: 10) and further provides conjugates in which a heart homing peptide is linked to a moiety such as a therapeutic agent. The conjugates of the invention are useful for treating cardiovascular diseases such as atherosclerosis and restenosis.
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申请公布号 |
US6303573(B1) |
申请公布日期 |
2001.10.16 |
申请号 |
US19990326718 |
申请日期 |
1999.06.07 |
申请人 |
THE BURNHAM INSTITUTE |
发明人 |
RUOSLAHTI ERKKI;MACKENNA DEIDRE A. |
分类号 |
A61K38/00;A61K47/48;A61P9/00;C07K7/06;C07K7/08;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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