摘要 |
A compound selected from those of formula (I):wherein:X represents oxygen, sulphur, or NR3 wherein R3 is as defined in the description,Y represents oxygen, sulphur, NR3, or may represent single bond in certain cases,T represents nitrogen, carbon, or CH,A represents single bond, alkylene, arylene, cycloalkylene, heterocycloalkylene, heteroarylene, or -SO2-R4- wherein R4 is as defined in the description,W represents hydroxy, alkoxy, aryloxy, arylalkoxy, cycloalkyloxy, heterocycloalkyloxy or heteroaryloxy, or hydroxyamino,U1 represents hetero, or alkylene wherein one or more of carbon may optionally be replaced by one or more hetero atoms,V1 represents arylene, heteroarylene,or heterocycloalkylene,U2 represents single bond, hetero or alkylene wherein one or more carbon may optionally be replaced by one or more hetero atoms,V2 represents aryl, heteroaryl, or heterocycloalkyl,Ra, Rb, Rc, which may be identical or different, each independently of the others represents a group as defined in the description,R1 represents aryl substituted by from one to five substituents, 1,3-dihydro-2H-indol-2-one, 3,4-dihydro-2(1H)-quinolinone, 1-hydroxy-2(1H)-pyridinone group, or heteroaryl,R2 represents halogen, alkyl, aryl, arylalkyl, cycloalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl,its isomers, and pharmaceutically-acceptable acid or base addition salts thereof, and medicinal products containing the same which are useful as inhibitors of PAI-1 in the treatment of thrombosis, pathologies for which the origin is thrombosis, or pathologies causing an increase in risk of thrombosis.
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