| 摘要 |
Device ( 1 ) for assaying a particulate analyte, comprising (a) a receptacle ( 2 ) for receiving a suspension ( 5 ) of particulate analyte, and containing label ( 3 ) for the particulate analyte, and (b) a porous detection material ( 4 ) that is permeable to label ( 3 ) but is impermeable to particulate analyte, the detection material ( 4 ) being arranged within receptacle ( 2 ) such that introduction of suspension ( 5 ) of particulate analyte into receptacle ( 2 ) forms liquid communication between label ( 3 ) and detection material ( 4 ). After liquid sample ( 5 ) is introduced into the receptacle ( 2 ), capillary flow through the porous detection material ( 4 ) begins. Particulate analyte cannot flow through the detection material ( 4 ) and is captured at its surface. Addition of liquid sample ( 5 ) also releases the label ( 3 ) within the receptacle ( 2 ), which is then free to flow through the detection material ( 4 ). Label ( 3 ) encounters the captured analyte and gives a signal ( 7 ). Label is prevented from running ahead of the analyte, resulting in high sensitivity. |
