摘要 |
<p>Compounds having potent antimicrobial effects over Gram-positive bacteria and Gram-negative bacteria, high stability to beta -lactamases and DHP-I and high safety for the human body and a process for producing the same. Carbapenem compounds represented by the following general formula (I) or salts thereof: <CHEM> wherein the ring A represents a 3- to 7-membered ring containing at least one nitrogen atom and optionally having a substituent other than R<6>; R<1> represents hydrogen or methyl; R<2> and R<5> are the same or different and each represents hydrogen or a protecting group of the hydroxyl group; R<3> represents hydrogen or a protecting group of the carboxyl group; R<4> represents hydrogen, lower alkyl or a protecting group of the amino group; R<6> represents: (1) hydrogen, (2) lower alkyl optionally substituted by optionally protected hydroxy, carbamoyl, formimidoyl, acetimidoyl or <CHEM> wherein R<7> and R<8> are the same or different and each represents hydrogen, lower alkyl, or a protecting group of the amino group), or (3) a protecting group of the amino group or a protecting group of the imino group; and m is 0 or 1. These compounds have antimicrobial effects and are useful as a drug.</p> |
申请人 |
EISAI CO., LTD. |
发明人 |
SATO, NOBUAKI;SASHO, MANABU;KAMATA, ATSUSHI;SUZUKI, TAKAAKI;SUGIYAMA, ISAO;KATSU, KANEMASA;SUZUKI, TAKESHI |