Methods for detecting extracellular deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated beta -amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
申请公布号
WO0174374(A1)
申请公布日期
2001.10.11
申请号
WO2001US10705
申请日期
2001.04.04
申请人
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH;PODUSLO, JOSEPH, F.;WENGENACK, THOMAS, M.;CURRAN, GEOFFRY, L.
发明人
PODUSLO, JOSEPH, F.;WENGENACK, THOMAS, M.;CURRAN, GEOFFRY, L.