| 摘要 |
The present invention relates to a novel protein called Insulin-Responsive Sequence DNA Binding Protein-1 (IRSBP-1) and nucleotide sequences that encode it. IRSBP-1 is capable of binding to nucleic acid regions associated with genes that respond when cells are exposed to insulin or insulin-like factors. IRSBP-1 regulates genes important in mediating the insulin response in humans and animals and in regulating pathological conditions such as diabetes, obesity, insulin-resistant syndrome and cell proliferative disorders. The present invention provides nucleic acids that may be used as probes specific for hybridizing and detecting nucleic acid molecules that encode at least in part a region of the IRSBP-1 protein. Within the scope of the present invention are recombinant cells, tissues and animals containing non-naturally occurring recombinant nucleic acid molecules encoding IRSBP-1, including expression vectors for the expression of IRSBP-1, antibodies to the IRSBP-1 proteins, assays utilizing the IRSBP-1 polypeptide, and methods relating to all of the foregoing. Also within the scope of the present invention is the development of therapeutic and diagnostic agents that mimic, facilitate or inhibit the action of IRSBP-1, and/or are based on relationships to the structure and action of IRSBP-1.
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