| 发明名称 |
SMALL ORGANIC MOLECULE REGULATORS OF CELL PROLIFERATION |
| 摘要 |
The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting t he cell with a hedgehog agonist, such as the compounds depicted in Figures 32 a nd 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizi ng a normal ptc pathway or agonizing smoothened orhedgehog activity.
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| 申请公布号 |
CA2404413(A1) |
申请公布日期 |
2001.10.11 |
| 申请号 |
CA20012404413 |
申请日期 |
2001.03.30 |
| 申请人 |
CURIS, INC. |
发明人 |
PORTER, JEFFREY;BAXTER, ANTHONY DAVID;BOYD, EDWARD ANDREW;PRICE, STEPHEN;GUICHERIT, OIVIN M.;RUBIN, LEE E. |
| 分类号 |
C07D239/90;A61K8/49;A61K31/381;A61K31/422;A61K31/4355;A61K31/44;A61K31/4436;A61K31/497;A61K31/50;A61K31/517;A61K31/5377;A61P1/16;A61P7/00;A61P11/00;A61P17/00;A61P17/14;A61P19/08;A61P25/00;A61P43/00;C07D333/70;C07D405/12;C07D409/12;C07D409/14;C07D413/12;C07D417/12;C07D491/20;(IPC1-7):A61K31/50 |
主分类号 |
C07D239/90 |
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