| 摘要 |
<p>A compound comprising a target cell-specific portion and a cytotoxic portion characterised in that the target cell-specific portion comprises a humanised monoclonal antibody having specificity for polymorphic epithelial mucin (PEM), or an antigen binding fragment thereof, and the cytotoxic portion has endonucleolytic activity. Preferably, the target cell-specific portion comprises a humanised HMFG-1 antibody or an antigen binding fragment thereof. Advantageously, the cytotoxic portion is at least the catalytically active portion of a DNA endonuclease, e.g. a human DNA endonuclease I. The invention further provides nucleic acids encoding the compounds of the invention, and the use of such compounds in medicine, e.g. in the treatment of cancer.</p> |
