发明名称 |
Inhibitors of naaladase enzyme activity |
摘要 |
The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit NAcetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells. |
申请公布号 |
AU739443(B2) |
申请公布日期 |
2001.10.11 |
申请号 |
AU19970039821 |
申请日期 |
1997.08.15 |
申请人 |
GUILFORD PHARMACEUTICALS INC. |
发明人 |
PAUL F. JACKSON;BARBARA S. SLUSHER;KEVIN L. TAYS;KEITH M. MACLIN |
分类号 |
A61K45/00;A61K31/194;A61K31/34;A61K31/38;A61K31/405;A61K31/44;A61K31/66;A61K31/662;A61K38/05;A61K38/06;A61K38/55;A61P13/08;A61P35/00;C07D209/04;C07D213/16;C07D307/34;C07D333/04;C07F9/22;C07F9/28;C07F9/30;C07F9/38 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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