CYCLIC LACTAMS AS INHIBITORS OF A.BETA. PROTEIN PRODUCTION

摘要

This invention relates to novel cyclic malonamides having the formula (I): t o their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A.beta.-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to .beta.-amyloid production such as Alzheimer's disease a nd Down's Syndrome.