| 发明名称 |
PHOSPHORAMIDATE PRODRUGS |
| 摘要 |
Novel phosphoramidate derivatives of hydroxy functional or amino functional compounds, including amino acids, peptides, peptidomimetics and nucleotide analogs, are described. The compounds enable enhanced intracellular delivery of drugs as their corresponding phosphate esters or amides. Described phosphoramidate compounds exhibit antiproliferative activity. Pharmaceutical formulations are provided for treatment of cancers.
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| 申请公布号 |
WO0174827(A1) |
申请公布日期 |
2001.10.11 |
| 申请号 |
WO2001US10163 |
申请日期 |
2001.03.30 |
| 申请人 |
PURDUE RESEARCH FOUNDATION |
发明人 |
BORCH, RICHARD, F.;TOBIAS, SANDRA, C.;GARRIDO-HERNANDEZ, HUGO |
| 分类号 |
A61K45/00;A61K31/165;A61K31/167;A61K31/7068;A61K31/7072;A61K38/00;A61P35/00;A61P43/00;C07F9/09;C07F9/24;C07F9/26;C07F9/6539;C07F9/655;C07F9/6553;C07H19/10;(IPC1-7):C07F9/26;A61K31/66;A61K31/70 |
主分类号 |
A61K45/00 |
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