A process for conveniently and industrially advantageously producing amine derivatives having effects of inhibiting the secretion and accumulation of amyloid beta protein. In compounds (I), the ether bond is selectively severed without severing the amide bond which is present in the same molecule and tertiary amines are not converted into quaternary salts. Thus, amine derivatives (V) with good qualities having effects of inhibiting the secretion and accumulation of amyloid ss protein can be obtained at a high yield.
申请公布号
WO0174756(A1)
申请公布日期
2001.10.11
申请号
WO2001JP02845
申请日期
2001.04.02
申请人
TAKEDA CHEMICAL INDUSTRIES, LTD.;YAMASHITA, MAKOTO;KATO, KANEYOSHI;TAWADA, HIROYUKI