MEDICAL DEVICES SUITABLE FOR GENE THERAPY REGIMENS

摘要

An implantable or insertable medical device suitable for gene or cell therap y regimens, and method of making and using same are disclosed. The medical device contains a biocompatible structure carrying a genetic material. The biocompatible structure includes a polymeric coating that coats at least a portion of the structure. The genetic material includes a first therapeutic agent comprising a vector containing a first polynucleotide sequence that establishes a gene expression sufficient to produce a therapeutically sufficient amount of one or more products encoded by said first polynucleotide; and a second therapeutic agent comprising at least one of (i ) a second polynucleotide carried by a carrier; (ii) a protein; (iii) a non- genetic therapeutic agent; or (iv) cells. The medical device and method of this invention facilitate successful integration as and long term expression of one or more genetic-based and non-genetic based products within a patient 's body.