发明名称 Partially saturated calcium channel blockers
摘要 Compounds of the formula or the salts thereof, wherein each Z is independently N or CH, but one Z must be N; wherein n1 is 1 and n2 is 0 or 1; X1 and X2 are linkers; Ar represents one or two substituted or unsubstituted aromatic or heteroaromatic rings, and Cy represents one or two substituted or unsubstituted aliphatic cyclic or heterocyclic rings, or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic ring and one substituted or unsubstituted aromatic or heteroaromatic ring; each of Ya and Yb is two substituted or unsubstituted aromatic or heteroaromatic rings, or can be two substituted or unsubstituted aliphatic cyclic or heterocyclic rings or consists of one substituted or unsubstituted aliphatic cyclic or heterocyclic ring and one substituted or unsubstituted aromatic or heteroaromatic ring; with the proviso that said rings cannot both be phenyl when both Ar includes a single phenyl ring and X1 contains less than 5C; and with the proviso that formula (1b) must contain at least one aromatic or heteroaromatic ring; 11 is 0 or 1; R1 is substituted or unsubstituted alkyl (1-6C), substituted or unsubstituted aryl (6-10C) or substituted or unsubstituted arylalkyl (7-16C) optionally containing 1-4 heteroatoms selected from the group consisting of halo, N, P, O, and S or may independently be halo, OR, SR, NR2, OOCR, NROCR, COR, COOR, CONR2, CF3, CN or NO2, wherein R is H or alkyl (1-6C).
申请公布号 US2001029258(A1) 申请公布日期 2001.10.11
申请号 US20010818063 申请日期 2001.03.26
申请人 SNUTCH TERRANCE P. 发明人 SNUTCH TERRANCE P.;ZAMPONI GERALD W
分类号 A61K31/4468;A61K31/451;A61K31/4515;A61K31/454;A61K31/495;A61K31/506;A61K31/5375;C07B61/00;C07D211/14;C07D211/16;C07D211/46;C07D295/02;C07D295/03;C07D295/073;C07D295/185;C07D401/04;C07D401/14;(IPC1-7):A61K31/537;A61K31/445 主分类号 A61K31/4468
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