| 摘要 |
The present invention relates to erythromycin A derivatives of the formula: and to pharmaceutically acceptable salts, prodrugs, tautomers, and solvates, thereof, wherein X1 is -CO-, -CH(NR5R6)-, -CHR5NR6-, -C(=NR5) - or -C(=NOR5)-; B is O, (CRaaRbb)m, SO2 or NR4; m is 0 or 1; Raa and Rbb are each H or alkyl or together form a ring; R1 is alkyl, aryl or aralkyl; R2 is H, alkyl, or the like; R3 is H, CO-alkyl or the like; R10 is OCONR11R12; R5 and R6 are each H, alkyl or the like or together form a ring; R4 is H, alkyl or the like; R11 is H or alkyl; and R12 is H, alkyl or the like.
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