发明名称 |
ARYLPROPENYLIMIDAZOLES AS FARNESYL-PROTEIN TRANSFERASE INHIBITORS |
摘要 |
This invention relates to compounds of formula (1), wherein substituents are defined in the description, that inhibit farnesylation of mutant ras gene products tough inhibition of the enzyme farnesyl-protein transferase (FPTase). The invention also relates to methods of manufacturing the compounds, pharmaceutical compositions and methods of treating diseases, especially cancer, which are mediated through farnesylation of ras. |
申请公布号 |
EP1140858(A2) |
申请公布日期 |
2001.10.10 |
申请号 |
EP19990962358 |
申请日期 |
1999.12.17 |
申请人 |
ASTRAZENECA AB |
发明人 |
ARNOULD, JEAN-CLAUDE;OLIVIER, ANNIE ANTOINETTE C. |
分类号 |
C07D233/58;A61K31/415;A61K31/4164;A61K31/4178;A61K31/454;A61K31/5377;A61P35/00;A61P43/00;C07D233/54;C07D233/61;C07D233/64;C07D409/06;C07D409/10;C07D409/12;C07D409/14;C07D521/00 |
主分类号 |
C07D233/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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