Novel nªÏ-acylated ª‡,ªÏ-diamino carboxylic acids and esters thereof and the preparation of same

摘要

The invention comprises Ne -palmitoyl-L-lysine and Ng - palmitoyl - (L - a ,g - diamino-butyric) acid and their alkyl esters containing up to six carbon atoms in the alkyl residue characterizing the ester group. The acids are prepared by heating L-lysine hydrochloride a L-a ,g -diamino-butyric acid hydrochloride with basic copper carbonate, acylating the resulting complex under alkaline conditions with palmitoyl chloride, acidifying the acylation product, removing the copper by precipitation with hydrogen sulphide and rendering the mixture neutral to precipitate the product. The acids are esterified by reaction with an alcohol and hydrogen chloride or thionyl chloride.