发明名称 |
Hydantoin intermediates for the synthesis of omapatrilat and methods for producing and using the same |
摘要 |
Omapatrilat (I) is a potent inhibitor of angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) both in vitro and in vivo and is currently undergoing large scale clinical trials as an anti-hypertensive. Omapatrilat may be synthesized using the S-stereoisomer of compound (V). Compound (V) may be prepared from a novel hydantoin (III). The hydantoin may be prepared from a monoacetal (XI) or via a dinitrile (V).
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申请公布号 |
US6300503(B1) |
申请公布日期 |
2001.10.09 |
申请号 |
US20000589571 |
申请日期 |
2000.06.07 |
申请人 |
DIXIE CHEMICAL COMPANY |
发明人 |
RONGIONE JOSEPH C.;BROWN ROBERT E.;RAFF DWIGHT E. |
分类号 |
C07C227/24;C07C229/22;C07D233/78;C07D317/30;C07D405/06;(IPC1-7):C07D233/02;C07D233/40 |
主分类号 |
C07C227/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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