发明名称 |
Process for preparing tissue factor pathway inhibitor |
摘要 |
In a process for preparing Tissue Factor Pathway Inhibitor (TFPI) by the genetically engineered technique by the use of a transformed animal cell wherein a DNA encoding human TFPI is introduced, the improvement which comprises culturing said transformed animal cell in a culture medium supplemented with a sulfated polysaccharide to protect an intact TFPI produced by said transformed animal cell from cleavage by proteases present in the culture medium.
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申请公布号 |
US6300100(B1) |
申请公布日期 |
2001.10.09 |
申请号 |
US19940266542 |
申请日期 |
1994.06.28 |
申请人 |
JURIDICAL FOUNDATION THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
KAMEI SHINTARO;KAMIKUBO YUICHI;HAMURO TSUTOMU |
分类号 |
C12N1/38;C07K14/81;C12N5/10;C12N15/09;C12P21/00;C12P21/02;C12P21/04;C12R1/91;(IPC1-7):C12N15/09;C12P21/06 |
主分类号 |
C12N1/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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