发明名称 |
AIDS virus vaccine with the use of sendai virus vector |
摘要 |
<p>The present invention provides a vaccine containing a Sendai virus vector encoding a virus protein of an immunodeficiency virus. By intranasally administering a Sendai virus encoding a virus protein of an immunodeficiency virus to a macaque monkey, the present inventors have succeeded in efficiently inducing protective immunity against an immunodeficiency virus. As a result of intranasal inoculation of vaccine, expression of an antigen protein mediated by Sendai virus vector was detected in intranasal mucous membrane and local lymph nodes and antigen-specific cellular immune response was induced at a significant level. No pathological symptom by vaccination was observed. After vaccination, exposure of simian immunodeficiency virus was performed and the effect was examined. As a result, the amount of virus in plasma significantly decreased, compared with that of the control animal. The vaccine of the present invention is promising as an AIDS vaccine.</p> |
申请公布号 |
AU4467501(A) |
申请公布日期 |
2001.10.08 |
申请号 |
AU20010044675 |
申请日期 |
2001.03.30 |
申请人 |
DNAVEC RESEARCH INC.;JAPAN AS REPRESENTED BY DIRECTOR-GENERAL NATIONAL INSTITUTE OF |
发明人 |
MUNEHIDE KANO;TETSURO MATANO;ATSUSHI KATO;YOSHIYUKI NAGAI;MAMORU HASEGAWA |
分类号 |
A61K39/21;A61K48/00;A61P31/18;C12N7/00;C12N15/86;C12N15/867 |
主分类号 |
A61K39/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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