发明名称 |
Methods of therapy for non-hodgkin's lymphoma using a combination of an antibodyto cd20 and interleuking-2 |
摘要 |
Methods for treating a mammal with lymphoma using a combination of interleukin-2 (IL-2) or variant thereof and at least one anti-CD20 antibody or fragment thereof are provided. These anti-tumor agents are administered as two separate pharmaceutical compositions, one containing IL-2 (or variant thereof), the other containing at least one anti-CD20 antibody (or fragment thereof), according to a dosing regimen. Administering of these two agents together potentiates the effectiveness of either agent alone, resulting in a positive therapeutic response that is improved with respect to that observed with either agent alone. The anti-tumor effects of these agents can be achieved using lower dosages of IL-2, thereby lessening the toxicity of prolonged IL-2 administration and the potential for tumor escape. |
申请公布号 |
AU4773701(A) |
申请公布日期 |
2001.10.08 |
申请号 |
AU20010047737 |
申请日期 |
2001.03.23 |
申请人 |
CHIRON CORPORATION;UNIVERSITY OF ROCHESTER |
发明人 |
MAURICE J. WOLIN;JOSEPH D ROSENBLATT |
分类号 |
A61K38/00;A61K39/395;A61P35/00;C07K16/28 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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