发明名称 Process for the preparation of 11-amino-3-chloro-6, 11-dihydro-5, 5-dioxo-6-methyl-dibenzo [C, F] [1, 2] Thiazepine and application to the synthesis of tianeptine.
摘要 Synthesis of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl dibenzo(c,f)(1,2)thiazepine (I) and its salts, from 3-chloro-6,11-dihydro-6-methyl-5,5,11-trioxo dibenzo(c,f)(1,2)thiazepine (III). Synthesis of 11-amino-3-chloro-6,11-dihydro-5,5-dioxo-6-methyl dibenzo(c,f)(1,2)thiazepine of formula (I) and its salts, from 3-chloro-6,11-dihydro-6-methyl-5,5,11-trioxo dibenzo(c,f)(1,2)thiazepine of formula (III): Independent claims are also included for the use of (I) to prepare tianeptine (II) and its salts.
申请公布号 ZA200102642(B) 申请公布日期 2001.10.05
申请号 ZA20010002642 申请日期 2001.03.30
申请人 ADIR ET COMPAGNIE 发明人 JACKY BLANCHARD;HUGUES TURBE;DANIEL BRIGOT
分类号 C07D281/12;A61K31/554;A61P25/22;A61P25/24;A61P43/00;B01J31/14;C07B61/00;C07D281/02 主分类号 C07D281/12
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