发明名称 |
COMPOSITIONS AND METHODS TO ENHANCE SENSITIVITY OF CANCER CELLS TO MITOTIC STRESS |
摘要 |
An isolated nucleic acid sequence of a mitotic checkpoint gene, <i>chfr</i>, encodes a Chfr protein having a Forkhead-associated domain and a Ring Finger. This protein is required for regulation of the transition of cells from prophase to metaphase during mitosis. The <i>chfr</i> nucleic acid and Chfr polypeptide are useful in diagnosing tumorigenic cells and in screening for drugs which can inhibit the activity of Chfr in a cancer cell, thereby rendering the cell more sensitive to additional anti-tumor therapies.
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申请公布号 |
WO0109150(A3) |
申请公布日期 |
2001.10.04 |
申请号 |
WO2000US16391 |
申请日期 |
2000.06.14 |
申请人 |
THE WISTAR INSTITUTE OF ANATOMY & BIOLOGY;HALAZONETIS, THANOS;SCOLNICK, DANIEL |
发明人 |
HALAZONETIS, THANOS;SCOLNICK, DANIEL |
分类号 |
C07K14/47;(IPC1-7):C07H21/04;C07K16/00 |
主分类号 |
C07K14/47 |
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