| 摘要 |
This invention provides methods for determining the genotype of organisms by hybridization analysis and, more specifically, to establishing the relatedne ss of individual organisms within a species. The present invention provides addressable arrays, comprising diversity panels of nucleic acid molecules, i n which the molecules on the array are addressable or uniquely identifiable in some fashion. A diversity panel is the result of a method that can distingui sh sequence differences between nucleic acid samples. As taught herein, a varie ty of methods may be used to generate diversity panels. Subsequent to the generation of the diversity panel, the nucleic acid products of the diversit y panel are separated for application onto an array. The separated diversity panel is then delivered onto a substrate to create an addressable array and hybridized with labeled nucleic acids. The genotype of an organism is determined by the pattern of hybridization.
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