| 摘要 |
<p>The present invention relates to a method for determining osteoporosis susceptibility by using genotypes of the androgen receptor gene. More specifically, the present invention relates to two distinct polymorphisms at the AR gene, namely, the CAG repeat coding for a polyglutamine tract and the GGC repeat coding for a polyglycine tract in the 5'part (exon 1) of the AR gene and to a linkage disequilibrium therebetween which can be correlated with a predisposition to osteoporosis and/or low bone density and/or high/low bone turnover and/or protection to osteoporosis. The invention further relates to kits for assessing such predispositions and/or protection. As well, the invention relates to osteoporosis susceptibility or to low bone mass, to responsiveness to treatment for osteoporosis, for osteoporosis prognosis or severity, or as a means to classify patients in clinical trial for osteoporosis (screening, diagnosis, prognosis or treatment). In addition, the invention relates to assays for screening drugs for osteoporosis or for determining the best treatment for osteoporosis.</p> |
