发明名称 |
CHAPERONE SUPPRESSION OF ATAXIN-1 AGGREGATION AND ALTERED SUBCELLULAR PROTEASOME LOCALIZATION IMPLY PROTEIN MISFILIND IN SCA1 |
摘要 |
The present invention provides a novel method for treating neurodegenerative disease in mammals. This method involves the introduction of a therapeutic effective amount of a chaperone, a chaperone-like-compound or a compound which increases proteasome activity into the neurological system of the mammal. There is also a novel method for screening for compounds having chaperone-like activity or having activity to increase proteasome activity. The screening works in either cultured cells or animal models.
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申请公布号 |
US2001027182(A1) |
申请公布日期 |
2001.10.04 |
申请号 |
US19990321916 |
申请日期 |
1999.05.28 |
申请人 |
ZOGHBI HUDA Y.;ORR HARRY T.;DEFRANCO DONALD B.;MANCINI MICHAEL A.;STENOIEN DAVID;CUMMINGS CHRISTOPHER J. |
发明人 |
ZOGHBI HUDA Y.;ORR HARRY T.;DEFRANCO DONALD B.;MANCINI MICHAEL A.;STENOIEN DAVID;CUMMINGS CHRISTOPHER J. |
分类号 |
G01N33/50;A61K38/00;A61K38/17;A61K45/00;A61K48/00;A61P25/00;C12N5/10;C12N15/09;G01N33/15;G01N33/68;(IPC1-7):A61K48/00;A01K67/00 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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