SINGLE CHAIN CLASS I MAJOR HISTO-COMPATIBILITY COMPLEXES, CONSTRUCTS ENCODING SAME AND METHODS OF GENERATING SAME

摘要

Methods of generating a functional mammalian single chain MHC class I comple x in prokaryotic expression systems and a functional human single chain MHC class I complex in eukaryotic or prokaryotic expression systems, which complexes are capable of presenting specific antigenic peptides restricted t o specific CTL clones.