REGULATION OF HUMAN SERINE RACEMASE ENZYME

摘要

Human serine racemase enzyme can be regulated to increase or decrease D-serine formation, which thereby results in a corresponding increase or decrease in NMDA receptor activation. A decrease in D-serine formation may aid in the prevention of neuron damage following an ischemic event, such as stroke. Regulation of D-serine formation may also aid in the treatment of other neurodegenerative conditions caused by the over- or under-activation of the glutamate NMDA receptor.