PROCESS FOR THE PREPARATION OF POLYMORPH OF 4-(ARYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENAMINE DERIVATIVE

摘要

A process for the preparation of a polymorph of 4-(aryl)-1,2,3,4-tetrahydro-1-naphthalenamine derivative, a hydrochloride salt of (1S,4S) N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine, comprising adding hydrochloride salt of (1S,4S) N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine to an alkanol - water solvent system, heating to dissolve and cooling the solution to allow crystallization to occur so as to obtain Form V.