| 摘要 |
The invention provides isolated nucleic acids molecules, designated GAP-4 nucleic acid molecules, which encode a novel family of GTPase activating proteins. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing GAP-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a GAP-4 gene has been introduced or disrupted. The invention still further provides isolated GAP-4 proteins, fusion proteins, antigenic peptides, and anti-GAP-4 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
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