3-oxy-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadazine-1,1-dioxide derivatives having diuretic and/or natriuretic activity

摘要

Compound of the formula wherein R1 is H, Cl, Br, F, trifluoromethyl, trichloromethyl, C1-C5-alkyl or C3-C7-cycloalkyl, optionally substituted with one or more hydroxy groups, halogen atoms, trifluoromethylgroups, amino or substituted aminogroups, nitrogroups or alkoxy or aryloxygroups, C1-C5-alkoxy, optionally substituted with one or more hydroxy groups, halogen atoms, trifluoromethylgroups, amino or substituted aminogroups, nitrogroups or alkoxy or aryloxygroups, NO2, NH2; X is SO2, C=O, C=S; R2 and R3 are independently H, C1-C5-alkyl or a C3-C7-cycloalkyl; R4 is H; C1-C10-alkyl (examples of which are methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl and isomers thereof); C1-C10-cycloalkyl; allyl; C1-C10-aryl (examples of which are optionally substituted phenyl, tolyl, xylyl) or heteroaryl; benzyl; C1-C10-alkenyl; C1-C10-(cyclo)alkenyl; C1-C10-ester; C1-C10-amide; polyethylene glycol ethers with 1 to 10 glycolunits; -C(O)N(R5)2;R5 is C1-C5-alkyl or C3-C7-cycloalkyl, optionally substituted with one or more hydroxy groups, halogen atoms, trifluoromethylgroups, amino or substituted aminogroups, nitrogroups or alkoxy or aryloxygroups, C1-C5-alkoxy optionally substituted with one or more hydroxy groups, halogen atoms, trifluoromethylgroups, amino or substituted aminogroups, nitrogroups or alkoxy or aryloxygroups, NO2, NH2; R6 is independently H, trifluoromethyl, trichloromethyl C1-C5-alkyl or C3-C7-cycloalkyl, optionally substituted with one or more hydroxy groups, halogen atoms, trifluoromethylgroups, amino or substituted aminogroups, nitrogroups or alkoxy or aryloxygroups, C1-C5-alkoxy optionally substituted with one or more hydroxy groups, halogen atoms, trifluoromethylgroups, amino or substituted aminogroups, nitrogroups or alkoxy or aryloxygroups; and salts, hydrolysable esters and/or solvates thereof.