发明名称 |
Modified blood clotting factors and methods of use |
摘要 |
The invention provides compositions including modified blood clotting factors that have a non-native proteolytic cleavage site engineered into them allowing intracellular cleavage and secretion of an active form. The compositions are useful in the methods for treating a bleeding or clotting disorder. |
申请公布号 |
AU4938901(A) |
申请公布日期 |
2001.10.03 |
申请号 |
AU20010049389 |
申请日期 |
2001.03.22 |
申请人 |
THE CHILDREN'S HOSPITAL OF PHILADELPHIA |
发明人 |
KATHERINE A. HIGH;PARIS MARGARITIS;RODNEY M. CAMIRE |
分类号 |
A61K38/00;A61K48/00;C07K14/745;C07K14/755 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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